Potassium Carbonate → 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate

HRID 377810

반응식

HRID 377810 반응식
[C:1]1([C:7]2([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([N:28]1[CH2:34][CH2:33][CH2:32][CH2:31][C:30]([C:43]2[CH:48]=[CH:47][C:46]([Cl:49])=[C:45]([Cl:50])[CH:44]=2)([CH2:35][CH2:36][CH2:37]OS(C)(=O)=O)[CH2:29]1)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[OH2:14].[ClH:49].[C:20]([N:28]1[CH2:34][CH2:33][CH2:32][CH2:31][C:30]([C:43]2[CH:48]=[CH:47][C:46]([Cl:49])=[C:45]([Cl:50])[CH:44]=2)([CH2:35][CH2:36][CH2:37][N:10]2[CH2:11][CH2:12][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:8][CH2:9]2)[CH2:29]1)(=[O:27])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1.[C:20]([N:28]1[CH2:34][CH2:33][CH2:32][CH2:31][C:30]([CH2:35][CH2:36][CH2:37][N:10]2[CH2:11][CH2:12][C:7]([C:13]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:14])([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:8][CH2:9]2)([C:43]2[CH:48]=[CH:47][C:46]([Cl:49])=[C:45]([Cl:50])[CH:44]=2)[CH2:29]1)(=[O:27])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1.[ClH:49]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 30194854-Phenyl-4-(pyrrolidin-1-ylcarbonyl)piperidineHCID 217029661-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-(methanesulfonyloxy)propyl]-perhydroazepine

생성물 1

HCID 1317216571-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate수율 31.7%

시약·촉매·용매 1

HCID 21891449acetonitrile N,N-dimethylformamide용매

실험 절차

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.96 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonyl)-piperidine, 1.5 g of the compound obtained in step C of EXAMPLE 13 and 1.5 g of K2CO3 in 10 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.34 g of the expected product, m.p.=135° C.

후처리

  1. customThis compound is prepared by the procedure

출처 및 근거

ORD 기록
ord-bb7f54aa765e4de4b72d387073878a58
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028082

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