Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Glycine, N-(3-nitrobenzoyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Glycine | HCID 750 | — |
| 반응물 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Glycine, N-(3-nitrobenzoyl)- | HCID 94858 | 82.8% |
반응 단계
A solution of glycine (200 g) and KOH (200 g) in water (1000 ml) at 0° C. was treated dropwise with a solution of m-nitrobenzoyl chloride (100 g) in acetonitrile (100 ml). The reaction was allowed to warm to room temperature and was stirred for 4 hours. 12N aqueous HCl was added until pH<2. The reaction was allowed to stand overnight at room temperature. The resulting solid was filtered and washed with water (2×250 ml) and dried in vacuo at 60° C. 100 g of m-nitrohippuric acid was isolated. MS, 1H-NMR and CHN analysis were consistent with the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06028223 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-41d8df0f332f499b89e651a9a30af4f3 |
| 출처 메모 | uspto-grants-2000_02 |