Lithium Hydroxide → 2-(Methylthio)pyrimidine-5-carboxylic acid

HRID 378317노트

반응식

HRID 378317 반응식
[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([O:11]CC)=[O:10])=[CH:5][N:4]=1.[Li+].[OH-]>O1CCOCC1>[CH3:1][S:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][N:4]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 10442716Ethyl 2-(methylthio)pyrimidine-5-carboxylate

생성물 1

HCID 36317942-(Methylthio)pyrimidine-5-carboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1 Eq. of 2-methylthio-5-ethoxycarbonylpyrimidine were dissolved in dioxane and, after addition of 2 eq. of 2N LiOH, stirred overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in EtOH. After addition of a stoichiometric amount of ethereal HCl, the solution was again evaporated to dryness. Water which was still present was removed by azeotropic drying with toluene once.

후처리

  1. customThe solvent was then removed under reduced pressure
  2. dissolutionthe residue was dissolved in EtOH
  3. additionAfter addition of a stoichiometric amount of ethereal HCl
  4. customthe solution was again evaporated to dryness
  5. customWater which was still present was removed
  6. dry with materialby azeotropic drying with toluene once

출처 및 근거

ORD 기록
ord-e11576c0d11348c29903a3f377fa8274
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06030972

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