Nitric Acid → 4-Methyl-3-nitrobenzonitrile

HRID 378320

반응식

HRID 378320 반응식
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]#[N:8])=[CH:3][CH:2]=1.[N+:10]([O-])([OH:12])=[O:11]>>[N+:10]([C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:1]=1[CH3:9])[C:7]#[N:8])([O-:12])=[O:11]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 7724p-Tolunitrile

생성물 1

HCID 5893334-Methyl-3-nitrobenzonitrile

실험 절차

399 g (2.56 mol) of p-toluonitrile were added over the course of 90 minutes to 1 l of fuming nitric acid at -10° C. 1 h after the addition, the mixture was poured onto 2.5 l of ice/H2O, whereupon a solid precipitated and was removed on a suction filter funnel and washed to neutral pH with water. The yield of the product was 363 g (88%). 1H-NMR (CDCl3 ; δ in ppm): 8.3 (d, 1H); 7.8 (dd, 1H); 7.5 (dd, 1H); 2.7 (s, 3H)

후처리

  1. addition1 h after the addition
  2. customprecipitated
  3. customwas removed on a suction
  4. filtrationfilter funnel
  5. washwashed to neutral pH with water

출처 및 근거

ORD 기록
ord-1caf7da4562c4aac9eba748c7266e898
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06030972

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