Hydrochloric Acid → Methyl 1-isopropyl-1H-indole-6-carboxylate

HRID 378372노트

반응식

HRID 378372 반응식
CO[CH:3](OC)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=1[NH:15][CH:16]([CH3:18])[CH3:17].Cl>CO>[C:11]([C:8]1[CH:7]=[C:6]2[C:5]([CH:4]=[CH:3][N:15]2[CH:16]([CH3:18])[CH3:17])=[CH:10][CH:9]=1)([O:13][CH3:14])=[O:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 193540554-Carbomethoxy-2-(N-2-propylamino)phenylacetaldehyde dimethylacetal

생성물 1

HCID 10608809Methyl 1-isopropyl-1H-indole-6-carboxylate수율 97.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-Carbomethoxy-2-(N-2-propylamino)phenylacetaldehyde dimethylacetal (3.7 g, 13.15 mmole) was refluxed with 100 mL of 1N hydrochloric acid in methanol for 1 h. The solution was concentrated and the residue dissolved in 50 mL of ethyl acetate, washed with saturated sodium bicarbonate solution, dried organic layer over magnesium sulfate and evaporated to give 2.78 g of 6-carbomethoxy-1-(2-propyl)indole.

후처리

  1. concentrationThe solution was concentrated
  2. dissolutionthe residue dissolved in 50 mL of ethyl acetate
  3. washwashed with saturated sodium bicarbonate solution, dried organic layer over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-ee653f7bebe748cdb1a83ef871bf4b78
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06030994

반응 노트

불러오는 중…