Sodium Hydroxide → N-(4-bromo-3-tert-butyl-5-isoxazolyl)benzenesulfonamide

HRID 378455노트

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HRID 378455 반응식
[C:1]1([S:7]([N:10]([C:20]2[O:24][N:23]=[C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])[C:21]=2[Br:29])S(C2C=CC=CC=2)(=O)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[Br:29][C:21]1[C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])=[N:23][O:24][C:20]=1[NH:10][S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 18617308N-Benzenesulfonyl-N-(4-bromo-3-tert-butyl-5-isoxazolyl) benzenesulfonamide

생성물 1

HCID 18617306N-(4-bromo-3-tert-butyl-5-isoxazolyl)benzenesulfonamide수율 94%

시약·촉매·용매 1

HCID 887Methanol용매2회

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온도
45 °C

실험 절차

N-Benzenesulfonyl-N-(4-bromo-3-tert-butyl-5-isoxazolyl)benzenesulfonamide (80 mg, 0.16 mmol) was dissolved in methanol (2 ml). Sodium hydroxide (0.120 g, 3.0 mmol) in methanol was added and the solution was stirred at 45° C. for 20 min. Methanol was removed under reduced pressure. The residue was dissolved in water, cooled to 0° C. and acidified to pH 3-4 with concentrated hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated in vacuo to give N-(4-bromo-3-tert-butyl-5-isoxazolyl)benzenesulfonamide in 94% yield. Further purification was achieved by recrystallization from methanol/water, giving an off white solid, m.p. 108-109° C.

후처리

  1. customMethanol was removed under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. temperaturecooled to 0° C.
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extract was dried over anhydrous magnesium sulfate
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9c44b7c9670d42b0956eb7c2d8d1738e
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06030991

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