1,4-Dioxane → 1-(4-Aminophenyl)piperidin-4-one

HRID 37847

반응식

HRID 37847 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.O1CCOCC1>[Ni].CO>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][C:13](=[O:16])[CH2:14][CH2:15]2)=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 312751,4-DioxaneHCID 38425621-(4-Nitrophenyl)piperidin-4-one

생성물 1

HCID 222202411-(4-Aminophenyl)piperidin-4-one수율 55.5%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A solution of 1-(4-nitro-phenyl)-piperidin-4-one (2.8 g, 12.7 mmol) in a mixture of 1:4 dioxane: methanol (100 mL) was hydrogenated over Raney nickel (1 g) under balloon pressure at ambient temperature overnight. The mixture was filtered through Celite and the filtrate was concentrated under vacuum. The resulting solid was washed with petroleum ether (2×10 mL) and dried to afford 1-(4-amino-phenyl)-piperidin-4-one (1.34 g, 55%).

후처리

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under vacuum
  3. washThe resulting solid was washed with petroleum ether (2×10 mL)
  4. customdried

출처 및 근거

ORD 기록
ord-9fd9cdc746864c5e85abe82bcbb9f9cc
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524705B2

연결된 노트

불러오는 중…