1-Phenyl-4-piperidinone → 1-Phenyl-piperidin-4-one oxime

HRID 37849

반응식

HRID 37849 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][OH:16]>CO>[C:1]1([N:7]2[CH2:12][CH2:11][C:10](=[N:15][OH:16])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 4130091-Phenyl-4-piperidinoneHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 3438331-Phenyl-piperidin-4-one oxime수율 92%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1-phenyl-piperidin-4-one (180 mg, 1.03 mmol) and hydroxylamine hydrochloride (142 mg, 2.06 mmol) in methanol (10 mL) was heated at reflux for 6 h. The solvent was evaporated and the residue diluted with water. The mixture was extracted with ethyl acetate then the organic phase was washed with water, brine, dried over anhydrous sodium sulfate and concentrated to afford 1-phenyl-piperidin-4-one oxime (0.18 g, 92%) as a liquid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 6 h
  3. customThe solvent was evaporated
  4. additionthe residue diluted with water
  5. extractionThe mixture was extracted with ethyl acetate
  6. washthe organic phase was washed with water, brine
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1a67ca0e59ef49e293898d43ff28ca5e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524705B2

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