Water → 5-(Bromomethyl)-2-chloropyridine

HRID 37855

반응식

HRID 37855 반응식
[Br:1]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][N:29]=1.O>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:34][C:31]1[CH:32]=[CH:33][C:28]([Cl:27])=[N:29][CH:30]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 5813932-Chloro-5-methyl-pyridine

생성물 1

HCID 64246615-(Bromomethyl)-2-chloropyridine

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

N-bromosuccinimide (6.1 g, 3.44 mmol) and benzoyl peroxide (218 mg, 0.09 mmol) were added successively to a solution of 2-chloro-5-methyl-pyridine (4.0 g, 3.13 mmol) in carbon tetrachloride (20 mL) and refluxed for 90 min. The reaction mixture was cooled to room temperature, water added and the organic layer separated. The organic layer was washed successively with water, brine, dried over anhydrous sodium sulfate and filtered. The resultant solution of 5-bromomethyl-2-chloro-pyridine was used as such for the next step.

후처리

  1. temperaturerefluxed for 90 min
  2. customthe organic layer separated
  3. washThe organic layer was washed successively with water, brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-19f91466f0b74cba80a0973a69dea6d8
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524705B2

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