Hydrochloric Acid → Methyl (1,2-benzoxazol-3-yl)acetate

HRID 378550

반응식

HRID 378550 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]COCC.Cl>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 3017292-(1,2-Benzoxazol-3-yl)acetic acid

생성물 1

HCID 2763403Methyl (1,2-benzoxazol-3-yl)acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1,2-benzisoxazole-3-acetic acid (prepared according to G. Casini et al, J. Het. Chem. 6, 1969, 279) (18 g), ether saturated with dry HCl (150 ml) and methanol (200 ml) was stirred for 2 h at room temperature. Removal of the volatiles in vacuo gave methyl 1,2-benzisoxazole-3-acetate (17 g) as an oil. The oil was dissolved in tetrahydrofuran (100 ml) and added dropwise to a suspension of lithium aluminium hydride (6 g) in tetrahydrofuran (200 ml) at 0-10° C. followed by stirring for 30 min at 15° C. Usual work-up gave 2-(1,2-benzisoxazol-3-yl)ethanol (13 g) as an oil.

후처리

  1. customRemoval of the volatiles in vacuo

출처 및 근거

ORD 기록
ord-ad19e0b454cd4ddc81a13c4262240dd0
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06031099

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