Hydrochloric Acid → Acridine
반응식
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=O.Cl>[OH-].[K+].O>[CH:4]1[CH:2]=[C:2]2[CH:4]=[C:6]3[C:11](=[N:1][C:8]2=[CH:7][CH:6]=1)[CH:10]=[CH:9][CH:8]=[CH:7]3참가 물질
5
실험 절차
The isatin product from step (a) was refluxed in 300 mL of 10% KOH solution in water for ca. 48 h. The solution was cooled and acidified to pH 2-3 with HCl. The yellow solid was suction filtered after 1 h and then washed with water. The solid was air-dried over night, washed with CH2Cl2 and then air-dried yielding 23.76 g of the acridine acid. 1H NMR (DMSO-d6) δ 7.72-8.30 (m, 7H).
후처리
- temperatureThe solution was cooled
- filtrationfiltered after 1 h
- washwashed with water
- customThe solid was air-dried over night
- washwashed with CH2Cl2
- customair-dried
출처 및 근거
- ORD 기록
- ord-e4e9027484294c6a9c469c5a4841e8ab
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06296787B1
반응 노트
불러오는 중…