Dimethylformamide diethylacetal → Ethyl 2-(6-chloropyridin-3-yl)-3-(dimethylamino)acrylate

반응식

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.C(O[CH:17](OCC)[N:18]([CH3:20])[CH3:19])C>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[CH:17][N:18]([CH3:20])[CH3:19])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 70913Dimethylformamide diethylacetal

HCID 15661146Ethyl 2-(6-chloropyridin-3-yl)acetate

생성물 1

HCID 72537728Ethyl 2-(6-chloropyridin-3-yl)-3-(dimethylamino)acrylate

반응 조건

온도: 90 °C

실험 절차

3.99 g (20.0 mmol) of the compound from Example 1A are dissolved in 13.7 ml of dimethylformamide diethyl acetal, and the mixture is stirred with microwave irradiation at 90° C. for 30 min. The mixture is then concentrated on a rotary evaporator, and the residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1).

후처리

concentrationThe mixture is then concentrated on a rotary evaporator
customthe residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1)

출처 및 근거

ORD 기록: ord-16cc391b4b8f4a33be01b15eb6e4129f
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08524699B2

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