Sodium Hydroxide → 2-(Propylthio)pyrimidine-4,6-diol

HRID 378841노트

반응식

HRID 378841 반응식
[CH2:1](I)[CH2:2][CH3:3].[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([SH:13])[N:7]=1.[OH-].[Na+]>O>[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([S:13][CH2:1][CH2:2][CH3:3])[N:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 336431-IodopropaneHCID 178516656HCID 178516656, 화합물

생성물 1

HCID 1784608102-(Propylthio)pyrimidine-4,6-diol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Propyl iodide (136 ml) was added to a suspension of 4,6-dihydroxy-2-mercaptopyrimidine (200 g) in water (800 ml), containing sodium hydroxide (55.6 g). The reaction mixture was stirred for 2 weeks then concentrated to half volume, 2N hydrochloric acid was added and the subtitle compound was isolated by filtration (167 g).

후처리

  1. concentrationthen concentrated to half volume, 2N hydrochloric acid
  2. additionwas added

출처 및 근거

ORD 기록
ord-6e83b0f2d6c14146a36cb58912dd272d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297232B1

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