Hydrazine hydrate (1:1) → (6-Morpholin-4-ylpyrimidin-4-yl)hydrazine
반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:3]=1.O.[NH2:15][NH2:16]>C(O)C>[NH:15]([C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:3]=1)[NH2:16]참가 물질
4
실험 절차
53.0 g (0.27 mol) of 4-(6-chloropyrimidin-4-yl)morpholine are initially charged in 260 ml of ethanol. 132.9 g (2.7 mol) of hydrazine hydrate are added, and the mixture is stirred under reflux for 16 h. The mixture is cooled to RT, and half of the solvent is removed by distillation. The mixture is then cooled to 0° C., and the solid formed is filtered off. The solid is washed with cold ethanol and initially air-dried and then dried under reduced pressure.
후처리
- temperatureunder reflux for 16 h
- customhalf of the solvent is removed by distillation
- temperatureThe mixture is then cooled to 0° C.
- customthe solid formed
- filtrationis filtered off
- washThe solid is washed with cold ethanol
- custominitially air-dried
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-7c389d41bf3a4ef4b3baa8420d5e64df
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524699B2
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