L-Tryptophan → L-Tryptophan, N-((4-fluorophenyl)sulfonyl)-

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C@@H:13]([CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1)[C:14]([OH:16])=[O:15]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C@@H:13]([CH2:17][C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][CH:19]=2)[C:14]([OH:16])=[O:15])(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 6305L-Tryptophan

HCID 95884-Fluorobenzenesulfonyl chloride

생성물 1

HCID 1091373L-Tryptophan, N-((4-fluorophenyl)sulfonyl)-

실험 절차

In a manner to Example 4 (a), 4-fluoro-benzenesulfonyl chloride was condensed with (S)-2-amino-3-(1H-Indol-3-yl)-propionic acid to give the title compound, mp=57-60° C.

출처 및 근거

ORD 기록: ord-8f83029d5bb041ad844c53b6606577e3
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06297247B1

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