Hydrochloric Acid → HCID 178433205, 화합물
반응식
[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:13][C:14]2[CH:26]=[CH:25][C:17]([O:18][CH2:19][C:20]([O:22]CC)=[O:21])=[CH:16][CH:15]=2)=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:27]>>[ClH:27].[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:13][C:14]2[CH:26]=[CH:25][C:17]([O:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:16][CH:15]=2)=[O:12])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]참가 물질
3
실험 절차
330 mg of ethyl {4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate are stirred at RT for 11 hrs. in 6 ml of 25% hydrochloric acid. The reaction mixture is evaporated to dryness in a vacuum and the residue is trituraited in MeCN. There are obtained 293 mg of [4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy]-acetic acid hydrochloride (1:1); m.p. 273° C., MS: 350 (M+H)+.
후처리
- customThe reaction mixture is evaporated to dryness in a vacuum
출처 및 근거
- ORD 기록
- ord-6c1f1892541943a5b69e8b7a019e8e00
- 출처 데이터셋
- uspto-grants-2001_10
- DOI