Hydrochloric Acid → HCID 21697102, 화합물

HRID 379039노트

반응식

HRID 379039 반응식
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([I:10])=[C:6]([O:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)[CH:5]=1.[Li+].[BH4-].O.Cl>C1COCC1>[I:10][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][OH:2])=[CH:5][C:6]=1[O:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 4148881Lithium borohydrideHCID 539211574-Iodo-3-(naphthalen-2-yloxy)-benzoic acid methyl ester

생성물 1

HCID 21697102HCID 21697102, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Iodo-3-(naphthalen-2-yloxy)-benzoic acid methyl ester (0.10 g, 0.25 mmol) dissolved in THF (2 mL) was treated with LiBH4 (2 M solution in THF) (0.247 mL, 0.495 mmol) and heated at reflux for 1.5 hr. The reaction mixture was cooled, added to H2O (50 mL)- concd HCl (4.3 mL), and extracted with EtOAc (3×30 mL). The organics were combined, washed with H2O, aq saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration to dryness gave the title compound which was used without purification.

후처리

  1. temperatureheated
  2. temperatureat reflux for 1.5 hr
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted with EtOAc (3×30 mL)
  5. washwashed with H2O, aq saturated NaHCO3 solution, brine
  6. dry with materialdried (Na2SO4)
  7. filtrationFiltration and concentration to dryness

출처 및 근거

ORD 기록
ord-070f5b911b604575881b4138dfcb6ac2
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297239B1

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