Potassium Carbonate → 2(1H)-Pyridinone, 1-(2-methoxyphenyl)-

HRID 379072

반응식

HRID 379072 반응식
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[OH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>[Cu].CCOC(C)=O>[O:10]=[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 68257o-IodoanisoleHCID 178516071HCID 178516071, 화합물

생성물 1

HCID 121913892(1H)-Pyridinone, 1-(2-methoxyphenyl)-

시약·촉매·용매 2

HCID 23978Copper촉매HCID 8857Ethyl Acetate용매

반응 조건

온도
200 °C

실험 절차

2-Iodoanisole (1.30 mL, 0.01 mol), 2-hydroxypyridine (0.95 g, 0.01 mol), anhydrous K2CO3 (2.76 g, 0.02 mol) and copper powder (0.0636 g, 0.001 mol) were combined and heated at 200° C. for 2 hr. The reaction mixture was cooled, EtOAc added, and filtered. The filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration gave the title compound after chromatography (silica gel, 2% CH3OH, CH2Cl2).

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. washThe filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine
  4. dry with materialdried (Na2SO4)
  5. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-4c3a55ba796041aab00b78a70ae21ba3
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297239B1

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