Potassium Carbonate → 2(1H)-Pyridinone, 1-(2-methoxyphenyl)-
반응식
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[OH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>[Cu].CCOC(C)=O>[O:10]=[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9]참가 물질
6
반응 조건
- 온도
- 200 °C
실험 절차
2-Iodoanisole (1.30 mL, 0.01 mol), 2-hydroxypyridine (0.95 g, 0.01 mol), anhydrous K2CO3 (2.76 g, 0.02 mol) and copper powder (0.0636 g, 0.001 mol) were combined and heated at 200° C. for 2 hr. The reaction mixture was cooled, EtOAc added, and filtered. The filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration gave the title compound after chromatography (silica gel, 2% CH3OH, CH2Cl2).
후처리
- temperatureThe reaction mixture was cooled
- filtrationfiltered
- washThe filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine
- dry with materialdried (Na2SO4)
- filtrationFiltration and concentration
출처 및 근거
- ORD 기록
- ord-4c3a55ba796041aab00b78a70ae21ba3
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06297239B1
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