Phosphorus tribromide → 4,6-Dimethyl-3-bromobenzofuran

반응식

[CH3:1][C:2]1[C:7]2[C:8](=O)[CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH3:12])[CH:3]=1.P(Br)(Br)[Br:14]>>[CH3:1][C:2]1[C:7]2[C:8]([Br:14])=[CH:9][O:10][C:6]=2[CH:5]=[C:4]([CH3:12])[CH:3]=1

참가 물질

반응물 2

HCID 24614Phosphorus tribromide

HCID 5955994,6-Dimethyl-3(2H)-benzofuranone

생성물 1

HCID 109002874,6-Dimethyl-3-bromobenzofuran수율 60%

반응 조건

온도: 100 °C

실험 절차

4,6-dimethyl-3-benzofuranone (0.90 moles) was slowly added in phosphorus tribromide (30 ml), previously heated to 100° C. The mix is cautiously treated with ice, extracted with methylenechloride. The organic phase is made anhydrous (Na2SO4) and freed from the solvent under reduced pressure to produce 4,6-dimethyl-3-bromobenzofuran (60% yield).

후처리

additionThe mix is cautiously treated with ice
extractionextracted with methylenechloride

출처 및 근거

ORD 기록: ord-32626ad5e31a49bbb5c2965f67b625d5
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06297387B1

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