Ammonium formate → N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

HRID 379474노트

반응식

HRID 379474 반응식
[CH3:1][N:2]([CH2:11][CH:12]([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH:18]([C:21]([C:23]2[N:27]([CH2:28][C:29]3[N:30](CC4C=CC=CC=4)[CH:31]=[CH:32][N:33]=3)[C:26]3[CH:41]=[CH:42][CH:43]=[CH:44][C:25]=3[N:24]=2)=[O:22])[CH2:17][CH2:16]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][N:2]([CH2:11][CH:12]([C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1)[CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][CH:18]([C:21]([C:23]2[N:27]([CH2:28][C:29]3[NH:33][CH:32]=[CH:31][N:30]=3)[C:26]3[CH:41]=[CH:42][CH:43]=[CH:44][C:25]=3[N:24]=2)=[O:22])[CH2:19][CH2:20]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 21697470N-methyl-N-(4-(4-(1-(1-benzylimidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

생성물 1

HCID 21697366N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Combine N-methyl-N-(4-(4-(1-(1-benzylimidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide (5 mmol) and 10% palladium-on-carbon (1.5 g) in methanol (50 mL). Add anhydrous ammonium formate (25 mmol). Heat to reflux. After 18 hours, filter, rinse with dichloromethane, and evaporate the filtrate in vacuo to give the title compound.

후처리

  1. temperatureHeat to reflux
  2. filtrationfilter
  3. washrinse with dichloromethane
  4. customevaporate the filtrate in vacuo

출처 및 근거

ORD 기록
ord-7caf438962724a72873b633243986422
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297259B1

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