Hydrochloric Acid → N-[3-(dimethylamino)propyl]acrylamide acrylamide N-dodecylacrylamide

HRID 379500

반응식

HRID 379500 반응식
[CH3:1][N:2]([CH3:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:10])[CH:8]=[CH2:9].[C:12]([NH2:16])(=[O:15])[CH:13]=[CH2:14].[CH2:17]([NH:29][C:30](=[O:33])[CH:31]=[CH2:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].Cl.Cl.N(C(C(=N)N)(C)C)=NC(C(=N)N)(C)C.Cl>O.C(O)C.C(O)(C)C>[CH3:11][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:10])[CH:8]=[CH2:9].[C:12]([NH2:16])(=[O:15])[CH:13]=[CH2:14].[CH2:17]([NH:29][C:30](=[O:33])[CH:31]=[CH2:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

9

반응물 5

HCID 313Hydrochloric AcidHCID 6579AcrylamideHCID 73929N-DodecylacrylamideHCID 763442,2'-Azobis(2-methylpropanimidamide) dihydrochlorideHCID 77452N,N-Dimethylaminopropyl acrylamide

생성물 1

HCID 86757470N-[3-(dimethylamino)propyl]acrylamide acrylamide N-dodecylacrylamide

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 3776Isopropanol용매

실험 절차

A solution of N-[3-(dimethylamino)propyl]acrylamide (30.0 g), acrylamide (13.6 g), and N-dodecylacrylamide (4.6 g) in deionized water (50 mL) and ethanol (50 mL) was heated to 60° C. under a nitrogen atmosphere. When the solution reached 60° C., 2,2′-azobis(2-amidinopropane)dihydrochloride (2.4 g of a 20 percent aqueous solution) was added. Heating was continued for 18 hours under a nitrogen atmosphere. After cooling to room temperature, the reaction solution was dissolved in isopropanol (150 mL), and concentrated HCl (29.5 g) was added with stirring. The solution was decanted from the precipitated polymer. The polymer was suspended in isopropanol (500 mL), stirred for at least 15 minutes, and allowed to settle. After decanting, the polymer was similarly washed an additional 3 times with isopropanol. The washed polymer was dried in a forced-air oven at 70° C. to afford 81.1 g.

후처리

  1. customreached 60° C.
  2. temperatureHeating
  3. customThe solution was decanted from the precipitated polymer
  4. stirringstirred for at least 15 minutes
  5. customAfter decanting
  6. washthe polymer was similarly washed an additional 3 times with isopropanol
  7. customThe washed polymer was dried in a forced-air oven at 70° C.
  8. customto afford 81.1 g

출처 및 근거

ORD 기록
ord-9009e46e0b55415a964d903f280d908b
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06299868B1

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