Potassium Carbonate → HCID 18366617, 화합물

HRID 379578노트

반응식

HRID 379578 반응식
C(=O)([O-])[O-].[K+].[K+].[CH3:7][N:8]1[C:13](=[O:14])[C:12]2[CH:15]=[CH:16][S:17][C:11]=2[NH:10][C:9]1=[O:18].[CH:19]1([CH2:22]Br)[CH2:21][CH2:20]1>CN(C)C=O.O>[CH3:7][N:8]1[C:13](=[O:14])[C:12]2[CH:15]=[CH:16][S:17][C:11]=2[N:10]([CH2:22][CH:19]2[CH2:21][CH2:20]2)[C:9]1=[O:18]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 15085573HCID 15085573, 화합물

생성물 1

HCID 18366617HCID 18366617, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Potassium carbonate (1.0 g) was added to a mixture of 3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (400 mg; J. Chem. Soc. Perkin Trans.1; 1980; 1853) and cyclopropylmethyl bromide (1.0 ml) in dry dimethylformamide (15 ml). The solution was stirred at room temperature for 20 hours and was then diluted with water and extracted thrice with diethyl ether. The combined organic extracts were washed with brine, then dried, filtered and evaporated. The residue was purified by column chromatography over silica, eluting with ethyl acetate: isohexane (1:4) to give the subtitle compound (180 mg).

후처리

  1. extractionextracted thrice with diethyl ether
  2. washThe combined organic extracts were washed with brine
  3. customdried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was purified by column chromatography over silica
  7. washeluting with ethyl acetate: isohexane (1:4)

출처 및 근거

ORD 기록
ord-ee27424c39fd47c595507e3c3bc6ca53
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300334B1

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