Ethanol → 6-(1H-Benzimidazol-1-ylmethyl)-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

HRID 379599노트

반응식

HRID 379599 반응식
[BH4-].[Na+].[CH3:3][N:4]1[C:9](=[O:10])[C:8]2[C:11]([S:16][CH:17]([CH3:19])[CH3:18])=[C:12]([CH:14]=O)[S:13][C:7]=2[N:6]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:5]1=[O:24].[CH2:25](O)[CH3:26]>O>[N:4]1([CH2:14][C:12]2[S:13][C:7]3[N:6]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:5](=[O:24])[N:4]([CH3:3])[C:9](=[O:10])[C:8]=3[C:11]=2[S:16][CH:17]([CH3:19])[CH3:18])[C:9]2[CH:8]=[CH:11][CH:12]=[CH:25][C:26]=2[N:6]=[CH:5]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 183665731,2,3,4-Tetrahydro-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-6-carboxaldehyde

생성물 1

HCID 183666216-(1H-Benzimidazol-1-ylmethyl)-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium borohydride (0.11 g) was added to 1,2,3,4-tetrahydro-3-methyl-5-[(1-methylethyl)thio]-1-(2-methylpropyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-6-carboxaldehyde (0.50 g) in ethanol (20 ml) and the mixture was stirred for 24 hours. The reaction was diluted with water (50 ml) and was then extracted with ethyl acetate (3×50 ml). The organic phases were washed with brine and then dried, filtered and evaporated to give the subtitle compound as a yellow solid (0.45 g).

후처리

  1. extractionwas then extracted with ethyl acetate (3×50 ml)
  2. washThe organic phases were washed with brine
  3. customdried
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-0ca9d0697f254f8d833948d11c2c88b1
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300334B1

반응 노트

불러오는 중…