Morpholine → (R)-2-Hydroxy-1-morpholinopropan-1-one
반응식
[C:1]([O:6]C)(=O)[C@@H:2]([CH3:4])[OH:3].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>C(OCC)(=O)C>[OH:3][C@H:2]([CH3:4])[C:1]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)=[O:6]참가 물질
4
반응 조건
- 온도
- 85 °C
실험 절차
A mixture of methyl (R)-lactate (175 g) and morpholine (440 ml, 3 eq) was heated at 85° C. for 40 h. The mixture was evaporated under reduced pressure. Purification of the residue by silica gel chromatography (using n-hexane:ethyl acetate=1:1 ˜ethyl acetate as an eluent) gave 4-[(R)-2-hydroxypropionyl]morpholine (232.4 g, 87% yield) as a pale yellow oil.
후처리
- customThe mixture was evaporated under reduced pressure
- customPurification of the residue by silica gel chromatography (
출처 및 근거
- ORD 기록
- ord-94c4aacdfda3451caec808415054f4a0
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06300353B1
반응 노트
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