Diethyl[2-(4-nitrophenoxy)ethyl]amine → 4-(2-(Diethylamino)ethoxy)aniline

HRID 379699

반응식

HRID 379699 반응식
[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]>[C].[Pd].CO>[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]

참가 물질

4

반응물 1

HCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

생성물 1

HCID 4189324-(2-(Diethylamino)ethoxy)aniline수율 98.4%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

N,N-diethyl-2-(4-nitrophenoxy)ethylamine (28.19 g) was dissolved into methanol (300 ml) and subjected to hydration reaction at ambient pressure by adding 10% palladium carbon catalyst (1.5 g). After completion of hydration reaction, catalyst was removed by filtration. Filtrate was concentrated under vacuum to obtain N,N-diethyl-2-(4-aminophenoxy)ethylamine (24.25 g) as color-less oily substance.

후처리

  1. customsubjected to hydration reaction at ambient pressure
  2. customAfter completion of hydration reaction, catalyst
  3. customwas removed by filtration
  4. concentrationFiltrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-72a8bec4006c486aac01b693cc55603e
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300368B1

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