[3,4-Bis(methoxymethoxy)]phenacyl chloride → 3-Amino-6-chloro-1-ethoxycarbonyl-2-[[3,4-bis(methoxymethoxy)]benzoyl]indole
반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.[CH3:16][O:17][CH2:18][O:19][C:20]1[CH:21]=[C:22]([CH:27]=[CH:28][C:29]=1[O:30][CH2:31][O:32][CH3:33])[C:23](=[O:26])[CH2:24]Cl>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:24]=1[C:23](=[O:26])[C:22]1[CH:27]=[CH:28][C:29]([O:30][CH2:31][O:32][CH3:33])=[C:20]([O:19][CH2:18][O:17][CH3:16])[CH:21]=1참가 물질
3
실험 절차
The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and [3,4-bis(methoxymethyloxy)]phenacyl chloride (step 1). 1H-NMR (CDCl3) δ: 8.25 (1H, d, J=1.8 Hz), 7.61 (1H, d, J=2.2 Hz), 7.52 (1H, d, J=8.0 Hz), 7.39 (1H, dd, J=8.4, 1.8 Hz), 7.29 (1H, dd, J=8.4, 1.8 Hz), 7.18 (1H, d, J=8.4 Hz), 5.72 (2H, br s), 5.29 (2H, s), 5.25 (2H, s), 3.86 (2H, q, J=7.3 Hz), 3.52 (6H, s), 0.91 (3H, t, J=7.3 Hz).
출처 및 근거
- ORD 기록
- ord-dbbfe8ad8a194b5182654b6774b19ae1