Potassium Iodide → 2-(3-Bromophenoxy)acetamide

HRID 380008노트

반응식

HRID 380008 반응식
Cl[CH2:2][C:3]([NH2:5])=[O:4].[Br:6][C:7]1[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[Br:6][C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=1)[O:13][CH2:2][C:3]([NH2:5])=[O:4]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 6580ChloroacetamideHCID 11430Potassium CarbonateHCID 115633-Bromophenol

생성물 1

HCID 78183782-(3-Bromophenoxy)acetamide수율 103.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 2-chloroacetamide (5.6 g), 3-bromophenol (10 g), potassium carbonate (8.3 g) and potassium iodide (1 g) in acetonitrile was stirred at room temperature for 72 hours. The resulting mixture was filtered, and the solids washed with ethyl acetate, and then water. The dried solids were recrystallised from boiling ethanol: water(8:2) to give the sub-title compound as a solid (13.8 g).

후처리

  1. filtrationThe resulting mixture was filtered
  2. washthe solids washed with ethyl acetate
  3. customThe dried solids were recrystallised

출처 및 근거

ORD 기록
ord-763d6c90d8df49af866b04a4a9d681f2
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300352B1

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