Acetic Acid → 4-Bromo-2-methylbenzene-1-sulfonamide

HRID 380043노트

반응식

HRID 380043 반응식
[Br:1][C:2]1[CH:3]=C([CH:6]=[CH:7][C:8]=1C)N.N([O-])=O.[Na+].Cl.[Cl-].[Mg+2].[Cl-].[S:18](=[O:20])=[O:19].[OH-].[NH4+:22].[C:23](O)(=O)[CH3:24]>[Cu](Cl)Cl>[Br:1][C:2]1[CH:8]=[CH:7][C:6]([S:18]([NH2:22])(=[O:20])=[O:19])=[C:23]([CH3:24])[CH:3]=1

참가 물질

9

반응물 7

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1119Sulfur DioxideHCID 14923Ammonium HydroxideHCID 82187Benzenamine, 3-bromo-4-methyl-HCID 5360315Magnesium ChlorideHCID 23668193Sodium Nitrite

생성물 1

HCID 206167674-Bromo-2-methylbenzene-1-sulfonamide

시약·촉매·용매 1

HCID 24014Cupric Chloride촉매

실험 절차

Prepared by the method of Example 69a) using 3-bromo-4-methylaniline (2.60 g, Example 78a)), sodium nitrite (1.05 g), concentrated hydrochloric acid (20 ml), anhydrous magnesium chloride (2.6 g), acetic acid saturated with sulfur dioxide (50 ml) and copper (II) chloride (0.37 g). The normal work-up and subsequent treatment with ammonium hydroxide (50 ml) followed by the same work-up afforded the subtitle compound as a solid (1.51 g).

후처리

  1. customPrepared by the method of Example 69a)

출처 및 근거

ORD 기록
ord-6eed423eaf45419abf435b98bb927e2c
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300352B1

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