Thionyl Chloride → 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl chloride

반응식

[C:1]1(=[O:15])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12])[C:4](=[O:14])[CH:3]=[CH:2]1.S(Cl)([Cl:18])=O>>[C:1]1(=[O:15])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([Cl:18])=[O:12])[C:4](=[O:14])[CH:3]=[CH:2]1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 5736836-Maleimidohexanoic acid

생성물 1

HCID 114247166-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl chloride

실험 절차

The 6-maleimidocaproic acid is reacted with excess thionyl chloride at 50° C. for three hours, and then the excess thionyl chloride is distilled off to leave 6-maleimidocaproic chloride.

후처리

distillationthe excess thionyl chloride is distilled off

출처 및 근거

ORD 기록: ord-ef01a791a26a42228eb1b16dad10abed
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06300456B1

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