tert-Butanol → ClCF2-CH2-O-CF2CFHBr

HRID 380085

반응식

HRID 380085 반응식
[Cl:1][C:2]([CH2:5][OH:6])([F:4])[F:3].C(O)(C)(C)C.[OH-].[K+].[C:14](=[C:17]([Br:19])[F:18])([F:16])[F:15]>O>[Cl:1][C:2]([CH2:5][O:6][C:14]([CH:17]([Br:19])[F:18])([F:16])[F:15])([F:4])[F:3].[C:2](=[CH:5][O:6][C:14]([CH:17]([Br:19])[F:18])([F:16])[F:15])([F:4])[F:3]

참가 물질

7

반응물 4

HCID 6386tert-ButanolHCID 117301-Bromo-1,2,2-trifluoroetheneHCID 14797Potassium HydroxideHCID 38641482-Chloro-2,2-difluoroethan-1-ol

생성물 2

HCID 21696368ClCF2-CH2-O-CF2CFHBr수율 89%HCID 88022705HCID 88022705, 화합물수율 11%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a 50 ml glass reactor equipped with PTFE valve and magnetic stirring, 2.4 g (0.02 moles) of ClCF2—CH2—OH, 5 ml of tert-butyl alcohol, 1.1 g (0.02 moli) of KOH and 3.5 g of CF2═CFBr (0.022 moles) are fed. The reaction mixture is left under stirring at room temperature for three hours. The organic phase is then diluted with water, separated, washed twice with slightly acid water by HCl and anhydrified. 5 g of a mixture having the following composition: 89% ClCF2—CH2—O—CF2CFHBr and 11% CF2═CH—O—CF2CFHBr are obtained.

후처리

  1. customIn a 50 ml glass reactor equipped with PTFE valve
  2. waitThe reaction mixture is left
  3. customseparated
  4. washwashed twice with slightly acid water by HCl

출처 및 근거

ORD 기록
ord-1dc9998e4b1d4138a80acbdb9350282f
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300526B1

연결된 노트

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