4-Chlorophenol → HCID 15482077, 화합물

HRID 380242노트

반응식

HRID 380242 반응식
[H-].[Na+].Cl[C:4]1[C:5]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:6]=2[S:7][C:8]=1[CH:9]=[O:10].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1>CN(C)C=O>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:4]2[C:5]3[CH:14]=[C:13]4[O:15][CH2:16][O:17][C:12]4=[CH:11][C:6]=3[S:7][C:8]=2[CH:9]=[O:10])=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 46844-ChlorophenolHCID 24758Sodium hydrideHCID 17820729HCID 17820729, 화합물

생성물 1

HCID 15482077HCID 15482077, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1 equivalent of sodium hydride and then 0.094 mol of the product obtained in Step D are added at ambient temperature and under an inert atmosphere to a solution of 0.10 mol of 4-chlorophenol in 250 ml of dimethylformamide. After 12 hours' reaction at 80° C., the reaction mixture is concentrated under reduced pressure. The residue is then diluted with ethyl acetate, washed with water and then with an aqueous solution of NaOH and then of NaCl, dried over calcium sulphate, filtered and concentrated under reduced pressure. Chromatography over silica gel (dichloromethane/ethyl acetate: 98/2) allows the expected product to be isolated.

후처리

  1. customAfter 12 hours' reaction at 80° C.
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. additionThe residue is then diluted with ethyl acetate
  4. washwashed with water
  5. dry with materialwith an aqueous solution of NaOH and then of NaCl, dried over calcium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customto be isolated

출처 및 근거

ORD 기록
ord-45198605680e4fbd866bbf6b8ae69d1d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06302837B1

반응 노트

불러오는 중…