HCID 18365075, 화합물 → 3-Aminopyridine-2-carbonitrile

HRID 380389

반응식

HRID 380389 반응식
[N:1]([C:4]1[C:5]([C:10]#[N:11])=[N:6][CH:7]=[CH:8][CH:9]=1)=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][C:4]1[C:5]([C:10]#[N:11])=[N:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 18365075HCID 18365075, 화합물

생성물 1

HCID 5770153-Aminopyridine-2-carbonitrile수율 98.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 3-azido-2-cyanopyridine (1.44 g, 9.9 mmol) in ethanol (100 ml) was hydrogenated over palladium on carbon (10%, 50 mg) at room temperature and 3.5 p.s.i for 18 h. The catalyst was filtered off over Celite and the filtrate was concentrated to leave the product (1.16 g). 1H NMR (d6-DMSO) 7.87 (1H, d), 7.33 (1H, dd), 7.22 (1H, d), 6.28 (2H, s).

후처리

  1. filtrationThe catalyst was filtered off over Celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-a4a17ec38cef4688a38ac0e63cc42f3b
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303613B1

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