Lawesson's reagent → 3-Amino-2-thiophenecarbothioamide

HRID 380394

반응식

HRID 380394 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:19])=CC=1>O1CCCC1>[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[S:19])[NH2:9]

참가 물질

4

반응물 2

HCID 87949Lawesson's reagentHCID 5189933-Aminothiophene-2-carboxamide

생성물 1

HCID 143211023-Amino-2-thiophenecarbothioamide수율 57.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-aminothiophene-2-carboxamide (4.5 g, 31 mmol) in tetrahydrofuran was treated with Lawesson's Reagent (7.7 g, 190 mmol) and the solution was stirred at room temperature for 18 h. The solvent was removed and the residue purified by chromatography on silica gel using dichloromethane as eluent. The product was obtained as a yellow powder (2.8 g, 56%), m.p. 98-99° C.

후처리

  1. customThe solvent was removed
  2. customthe residue purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-b8dbf243a8a842919d2cafadcf065e20
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303613B1

연결된 노트

불러오는 중…