Triethylamine → 2,4-Dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	Ethanamine, 2,2,2-trifluoro-	HCID 9773	—
반응물	2,4-Dichloropyrimidine-5-carbonyl chloride	HCID 13784112	—
용매	Dichloromethane	HCID 6344	—
생성물	2,4-Dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide	HCID 86664758	60%

반응 조건

온도	25 °C

반응 단계

2,4-Dichloropyrimidine-5-carbonyl chloride (1 g, 5 mmol) was dissolved in CH2Cl2 (20 mL), 2,2,2-trifluoroethylamine (515 mg, 5 mmol) and triethylamine (1.31 mL, 9 mmol) were added. The reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was purified by flash chromatography to yield a white solid (780 mg, 60%). MS: m/z=271.9 [M−H]−.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08524710B2
출처 데이터셋	uspto-grants-2013_09
ORD ID	ord-e3e74a819e39477187627512570c9e67
출처 메모	uspto-grants-2013_09