Pyridine → HCID 9801910, 화합물

HRID 380572노트

반응식

HRID 380572 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([CH2:14][NH2:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:28](Cl)(=[O:37])[C:29]1[C:30]([O:35][CH3:36])=[CH:31][CH:32]=[CH:33][CH:34]=1.CCOCC>CN(C)C1C=CN=CC=1.C(Cl)Cl>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([CH2:14][NH:15][C:28]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[O:35][CH3:36])=[O:37])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 1049PyridineHCID 3283Diethyl EtherHCID 889692-Methoxybenzoyl chlorideHCID 804238(1-Benzyl-4-phenylpiperidin-4-yl)methanamine

생성물 1

HCID 9801910HCID 9801910, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2.1 g (7.6 mmol) of 1-N-Benzyl-4-phenyl-4-aminomethylpiperidine and 1.2 mL of pyridine (15.2 mmol) and 20 mg of 4-dimethylaminopyridine (DMAP) in 20 mL of methylene chloride was added 2.6 g (15.2 mmol) of o-anisoyl chloride at 0° C. The reaction mixture was stirred for 12 hr and was poured into 200 ml of ether. It was washed with saturated NaHCO3 solution, dried over MgSO4 and concentrated. The residue was purified by chromatography (silica, hexanes: ethyl acetate, 1:4) to afford the title compound.

후처리

  1. washIt was washed with saturated NaHCO3 solution
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated
  4. customThe residue was purified by chromatography (silica, hexanes: ethyl acetate, 1:4)

출처 및 근거

ORD 기록
ord-6a00bd75ceaa4ad592af22f4a34b2aab
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06303637B1

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