Tetraethyltin → 7-Ethyl-5-nitro-1,3-benzothiazole
반응식
Br[C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.[CH2:14]([Sn](CC)(CC)CC)[CH3:15]>CCOC(C)=O>[CH2:14]([C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1)[CH3:15]참가 물질
4
실험 절차
A solution of 7-bromo-5-nitrobenzothiazole (0.15 g, 0.58 mmol), tetraethyltin (0.18 mL, 0.87 mmol) and catalytic amount of Cl2Pd(PPh3)2 in a sealed tube was stirred for 12 h at 90° C. The reaction mixture was diluted with EtOAc and washed with brine several times. Organic solution was dried over Na2SO4 and concentrated in vacuo, yielding an oil which was subjected to column chromatography (EtOAc, neat) to provide 91 mg (0.44 mmol, 75%) of the desired product.
후처리
- washwashed with brine several times
- dry with materialOrganic solution was dried over Na2SO4
- concentrationconcentrated in vacuo
- customyielding an oil which
출처 및 근거
- ORD 기록
- ord-f1220a4cbf964c148f62ecaec8b62f74
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06303643B1
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