Oxalyl chloride → 5-Chlorothiophene-2-carbonyl Chloride

HRID 38132

반응식

HRID 38132 반응식
[Cl:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:13])=O>CCOC(C)=O.CN(C=O)C>[Cl:1][C:2]1[S:6][C:5]([C:7]([Cl:13])=[O:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 950485-Chloro-2-thiophenecarboxylic acid

생성물 1

HCID 5892235-Chlorothiophene-2-carbonyl Chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 8857Ethyl Acetate용매

실험 절차

To a chilled solution of 5-chlorothiophene-2-carboxylic acid (0.16 g, 1.0 mmol) in EtOAc (3 mL) and DMF (1 drop) was added neat oxalyl chloride (92 μL, 1.05 mmol). The reaction mixture was stirred cold for 2 hr and concentrated in vacuo to give crude 5-chlorothiophene-2-carbonyl chloride.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f3ab523db84d4747a39bf21f2f7e9033
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524721B2

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