Acetic Anhydride → 3-Acetaminobenzyl alcohol

HRID 38157

반응식

HRID 38157 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1COCC1.CCOC(C)=O>[OH:6][CH2:5][C:4]1[CH:3]=[C:2]([NH:1][C:10](=[O:12])[CH3:11])[CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 802933-Aminobenzyl alcohol

생성물 1

HCID 966393-Acetaminobenzyl alcohol수율 85%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a chilled suspension of 3-aminobenzyl alcohol (9.24 g, 75 mmol) in THF (50 mL) was added neat acetic anhydride (8.1 mL, 86 mmol). The reaction mixture was stirred cold for 1 hr, diluted with EtOAc, washed with aq. NaOH and brine, and concentrated in vacuo to give N-[3-(hydroxymethyl)phenyl]acetamide (10.5 g, 85%).

후처리

  1. washwashed with aq. NaOH and brine
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cda3a113e7984ffbbcb9d5012335d664
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524721B2

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