3-Acetaminobenzyl alcohol → N-(3-formylphenyl)acetamide

HRID 38158

반응식

HRID 38158 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1>C1(C)C=CC=CC=1.O=[Mn]=O>[CH:2]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1)=[O:1]

참가 물질

4

반응물 1

HCID 966393-Acetaminobenzyl alcohol

생성물 1

HCID 256849N-(3-formylphenyl)acetamide수율 93%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매2회HCID 1140Toluene용매

실험 절차

A mixture of N-[3-(hydroxymethyl)phenyl]acetamide (10 g, 60.6 mmol) and MnO2 (7.8 g, 90 mmol) in toluene (250 mL) was refluxed for 29 hr, with addition of more MnO2 (0.7 g, 9 mmol) at 24 hr. The reaction was cooled, filtered through Celite and concentrated in vacuo to give N-(3-formylphenyl)acetamide (9.2 g, 75%). ES-MS (M+H)+=164.

후처리

  1. temperatureThe reaction was cooled
  2. filtrationfiltered through Celite
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-608dc77e9c7041d8a6b76f2f2709fde6
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524721B2

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