Methanol → Simvastatin

HRID 381710

반응식

HRID 381710 반응식
[CH3:1][CH2:2][C:3]([C:6]([O:8][C@@H:9]1[C@@H:14]2[C@@H:15]([CH2:20][CH2:21][C@H:22]3[O:28][C:26](=[O:27])[CH2:25][C@H:24]([OH:29])[CH2:23]3)[C@@H:16]([CH3:19])[CH:17]=[CH:18][C:13]2=[CH:12][C@H:11]([CH3:30])[CH2:10]1)=[O:7])([CH3:5])[CH3:4].B([O-])[O-].CO>O>[CH3:1][CH2:2][C:3]([C:6]([O:8][C@@H:9]1[C@@H:14]2[C@@H:15]([CH2:20][CH2:21][C@H:22]3[O:28][C:26](=[O:27])[CH2:25][C@H:24]([OH:29])[CH2:23]3)[C@@H:16]([CH3:19])[CH:17]=[CH:18][C:13]2=[CH:12][C@H:11]([CH3:30])[CH2:10]1)=[O:7])([CH3:5])[CH3:4]

참가 물질

4

반응물 2

HCID 887MethanolHCID 178445512HCID 178445512, 화합물

생성물 1

HCID 54454Simvastatin

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Alternatively, III may be agitated in a mixture of water and an organic solvent, preferably methanol, under high dilution conditions to produce simvastatin in its acid form. Simvastatin acid may be isolated by extraction or crystallization and relactonized to produce simvastatin.

출처 및 근거

ORD 기록
ord-fd52504a35e746cd8b8005092cc39f97
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307066B1

연결된 노트

불러오는 중…