Methanesulfonic Acid → Ethyl 4,4,4-trifluoro-3-hydroxybutanoate

HRID 381798

반응식

HRID 381798 반응식
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].CS(O)(=O)=O.[H][H]>[Pt]>[F:1][C:2]([F:11])([F:12])[CH:3]([OH:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

5

반응물 3

HCID 6395Methanesulfonic AcidHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 136210Ethyl 4,4,4-trifluoro-3-hydroxybutanoate수율 50.1%

시약·촉매·용매 1

HCID 23939Platinum촉매

반응 조건

온도
40 °C

실험 절차

Ethyl 4,4,4-trifluoroacetoacetate (50 g), under a blanket of nitrogen gas, is heated to 40° C. and treated with platinum (0.1 g of 5% Pt/C, 0.01% load) and methanesulfonic acid (1.5 g, 2.9% load). Hydrogen is charged to a pressure of 5 bars, and the mixture agitated at 40° C. for 6h. After filtration to remove the catalyst, 25.3 g (50% yield) of ethyl 4,4,4-trifluoro-3-hydroxybutyrate is obtained.

후처리

  1. filtrationAfter filtration
  2. customto remove the catalyst

출처 및 근거

ORD 기록
ord-d5a853887b8d4c2fb460537e3b147d6c
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06307094B1

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