1H-Pyrazol-3-amine, 5-methyl- → (2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

HRID 38192

반응식

HRID 38192 반응식
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:9](Cl)([N:10]=1)[N:8]=[CH:7][N:6]=2.[CH3:12][C:13]1[NH:17][N:16]=[C:15]([NH2:18])[CH:14]=1>C(O)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:9]([NH:18][C:15]3[CH:14]=[C:13]([CH3:12])[NH:17][N:16]=3)([N:10]=1)[N:8]=[CH:7][N:6]=2

참가 물질

4

반응물 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 219392112,4-Dichloro-purine

생성물 1

HCID 21939154(2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine수율 58%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 2,4-dichloro-purine (2.0 g, 10.6 mmol) in anhydrous ethanol (10 mL) was added 5-methyl-1H-pyrazol-3-yl amine (2.05 g, 21.2 mmol). The resulting mixture was stirred at room temperature for 48 h. The resulting precipitate was collected by filtration, washed with ethanol, and dried under vacuum to afford 1.524 g (58% yield) of (2-chloro-purin-4-yl)-(5-methyl-1H-pyrazol-3-yl)-amine which was used in the next step without further purification.

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethanol
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-05ebf093e1a14231a12db97afd039c30
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524720B2

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