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Lithium hydroxide, monohydrate → (Z)-4-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-5-[(2-thienylacetyl)amino]-1H-indol-4-yl]-benzoic acid

HRID 382069
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반응식

HRID 382069 반응식
C[O:2][C:3](=[O:37])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([NH:19][C:20](=[O:27])[CH2:21][C:22]3[S:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:16]=[C:15]3[C:11]=2/[C:12](=[CH:29]/[C:30]2[NH:31][CH:32]=[CH:33][C:34]=2[O:35][CH3:36])/[C:13](=[O:28])[NH:14]3)=[CH:6][CH:5]=1.O[Li].O>C1COCC1.O>[CH3:36][O:35][C:34]1[CH:33]=[CH:32][NH:31][C:30]=1/[CH:29]=[C:12]1\[C:13](=[O:28])[NH:14][C:15]2[C:11]\1=[C:10]([C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:37])=[O:2])=[CH:9][CH:8]=1)[C:18]([NH:19][C:20](=[O:27])[CH2:21][C:22]1[S:23][CH:24]=[CH:25][CH:26]=1)=[CH:17][CH:16]=2
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참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 9871087(Z)-4-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl) methylene]-2-oxo-5-[(2-thienylacetyl)amino]-1H-indol-4-yl]-benzoic acid methyl ester

생성물 1

HCID 9805948(Z)-4-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-5-[(2-thienylacetyl)amino]-1H-indol-4-yl]-benzoic acid수율 29%

시약·촉매·용매 2

HCID 962Water용매
HCID 8028
Tetrahydrofuran
용매

실험 절차

Using Method F above, (Z)-4-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-5-[(2-thienylacetyl)amino]-1H-indol-4-yl]-benzoic acid methyl ester (70 mg, 0.14 mmol) (from Example 50 supra) was hydrolyzed with LiOH.H2O (20 mg, 0.48 mmol) in THF (3 mL) and water (2 mL) at room temperature for 3 days to yield (Z)-4-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-5-[(2-thienylacetyl)amino]-1H-indol-4-yl]-benzoic acid (yield: 20 mg, 29%).

출처 및 근거

ORD 기록
ord-76834a2ec4ff47bea60d9694c29243f5
출처 데이터셋
uspto-grants-2001_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06307056B1

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