Formic Acid → 1,3-Benzoxazole-4-carboxylic acid
반응식
[NH2:1][C:2]1[C:10](N)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:12](O)=[O:13]>Cl>[O:13]1[C:10]2=[CH:9][CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]2[N:1]=[CH:12]1참가 물질
4
실험 절차
A mixture of 2,3-diaminobenzoic acid (0.5 g, 3.29 mmol) and formic acid (405 μl, 9.87 mmol) in hydrochloric acid (4M, 10 ml) was heated under reflux for one hour. The precipitate which formed on cooling was collected, redissolved in boiling methanol, and decolorised with activated charcoal. Evaporation of the solvent gave benzoxazole-4-carboxylic acid as a white powder (407.9 mg, 77%) Found: C, 46.11; H, 3.63; N, 13.27. C8H6N2O2.HCl.0.5 H2O requires C, 46.28; H, 3.88; N, 13.49%; δH (d6-DMSO, 200 MHz) 7.7-7.8; (1H, t, Ar-5H), 8.2-8.3 (2H, dd, Ar-4/6H), 9.65 (1H, s, imidazole-2H).
후처리
- temperaturewas heated
- temperatureunder reflux for one hour
- customThe precipitate which formed
- temperatureon cooling
- customwas collected
- dissolutionredissolved
- customEvaporation of the solvent
출처 및 근거
- ORD 기록
- ord-3eee5a06d86045f5a2db757251c83abd
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06310082B1
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