3-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide

HRID 382415

반응식

HRID 382415 반응식
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](Cl)=[O:26]>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:25](=[O:26])[C:24]3[CH:28]=[CH:29][CH:30]=[C:22]([F:21])[CH:23]=3)[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

참가 물질

3

반응물 2

HCID 743763-Fluorobenzoyl chlorideHCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide

생성물 1

HCID 183601861-(4-t-Butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide수율 70%

실험 절차

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.54 g (5.65 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and 3-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.57 g of 1-(4-t-butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide (yield 70%).

후처리

  1. customAn amidation reaction

출처 및 근거

ORD 기록
ord-847f5e17d08143969243a6780ae8fd50
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310070B1

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