1-[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-2-methylpropan-1-one → 1-(4-(4-Amino-2-chlorophenyl)piperazin-1-yl)-2-methylpropan-1-one

HRID 38248

반응식

HRID 38248 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH2:13][CH2:12]1>CCO.[Pt]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])[CH2:13][CH2:12]2)=[C:2]([Cl:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 28863371-[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-2-methylpropan-1-one

생성물 1

HCID 9369261-(4-(4-Amino-2-chlorophenyl)piperazin-1-yl)-2-methylpropan-1-one수율 100%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

According to Scheme 4 Step 2: A solution of 1-(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)-2-methylpropan-1-one (0.62 mmol, 195 mg) in EtOH (120 mL) was passed through a Pt/C 5% column in an H-Cube equipment (mode: Full). Then the solution was concentrated under reduced pressure to yield 1-(4-(4-amino-2-chlorophenyl)piperazin-1-yl)-2-methylpropan-1-one (0.62 mmol, 175 mg, 99%). The product was used without further purification.

후처리

  1. concentrationThen the solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-87ef60dc803e4ba19fb00fe856302c8e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524726B2

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