Diethyl Ether → (2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester

HRID 38259

반응식

HRID 38259 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[C:18]([O:22][C:23](=[O:26])[CH2:24]Br)([CH3:21])([CH3:20])[CH3:19].C(OCC)C>CN(C=O)C.O>[C:8]([C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[O:11][CH2:24][C:23]([O:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:26])(=[O:10])[CH3:9]

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 740613-Chloro-6-hydroxyacetophenoneHCID 79177tert-Butyl bromoacetate

생성물 1

HCID 67131695(2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1-(5-chloro-2-hydroxyphenyl)-ethanone (2 g), potassium carbonate (1.62 g) and tert-butylbromoacetate (1.73 ml) in DMF (5 ml) was stirred at ambient temperature for 16 h. Diethyl ether and water were added and the organic layer separated, it was washed with water, aqueous potassium carbonate solution, brine, dried (Na2SO4) and the solvent removed in vacuo to give the sub-title compound (2.84 g).

후처리

  1. customthe organic layer separated
  2. washit was washed with water, aqueous potassium carbonate solution, brine
  3. dry with materialdried (Na2SO4)
  4. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-e58e506d526849c4b183a9ac5b1d2265
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524715B2

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