Methanesulfonyl chloride → [4-chloro-2-(1-chloroethyl)phenoxy]-acetic Acid, 1,1-dimethylethyl Ester

HRID 38260노트

반응식

HRID 38260 반응식
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[C:4]([CH:17](O)[CH3:18])[CH:3]=1.CCN(C(C)C)C(C)C.CS([Cl:33])(=O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[C:4]([CH:17]([Cl:33])[CH3:18])[CH:3]=1

참가 물질

5

반응물 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 86631057[4-chloro-2-(1-hydroxyethyl)phenoxy]-acetic Acid, 1,1-dimethylethyl Ester

생성물 1

HCID 86631056[4-chloro-2-(1-chloroethyl)phenoxy]-acetic Acid, 1,1-dimethylethyl Ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the product of step b) (0.34 g) in DCM (5 ml) was added Hunigs base (1 ml) followed by methanesulfonyl chloride (0.46 ml) and the reaction stirred at room temperature for 2 h followed by heating at 45° C. for 2 h. After cooling to 0° C. the bulk of the volatiles were removed in vacuo. Diethyl ether and water were added and the organic layer separated.

후처리

  1. temperatureby heating at 45° C. for 2 h
  2. temperatureAfter cooling to 0° C. the bulk of the volatiles
  3. customwere removed in vacuo
  4. additionDiethyl ether and water were added
  5. customthe organic layer separated

출처 및 근거

ORD 기록
ord-751bf4b766aa40ed99c35ebfb6283106
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524715B2

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