Methyl iodide → HCID 178422144, 화합물

HRID 382621노트

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HRID 382621 반응식
[OH:1][C@@H:2]([C@H:4]1[C:33](=[O:34])[N:6]2[C:7]([C:20]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)=[O:21])=[C:8]([C:11]3[S:15][C:14]4=[CH:16][N:17]=[CH:18][N:13]4[C:12]=3[CH3:19])[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[I:35][CH3:36]>ClCCl>[I-:35].[CH3:19][C:12]1[N+:13]2[C:14](=[CH:16][N:17]([CH3:36])[CH:18]=2)[S:15][C:11]=1[C:8]1[C@H:9]([CH3:10])[C@@H:5]2[C@@H:4]([C@H:2]([OH:1])[CH3:3])[C:33](=[O:34])[N:6]2[C:7]=1[C:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][C:27]([N+:30]([O-:32])=[O:31])=[CH:28][CH:29]=1)=[O:21]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 120700444-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(3-methylimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate

생성물 1

HCID 178422144HCID 178422144, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 73.6 mg of 4-nitrobenzyl (1S,5R, 6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(3-methylimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate in 0.5 ml of dry dichloromethane was added 0.95 ml of iodomethane, and the mixture was stirred under the atmosphere of argon in the darkness at room temperature for 18 hours. Unreacted reagent was removed under reduced pressure to give 89.1 mg of 4-nitrobenzyl (1S,5R,6S)-2-(3,6-dimethylimidazo[5,1-b]thiazolium-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate iodide.

후처리

  1. customwas removed under reduced pressure

출처 및 근거

ORD 기록
ord-ccfb4c2ea0a040f58e7cca3712df7a7d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310056B1

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