Phenylacetyl chloride → [4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

HRID 38283노트

반응식

HRID 38283 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17](S(C3C=CC=CC=3)(=O)=O)[C@@H:16]([CH2:29][CH2:30][CH3:31])[CH2:15]2)[CH:3]=1.[C:32]1([CH2:38][C:39](Cl)=[O:40])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:39](=[O:40])[CH2:38][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C@@H:16]([CH2:29][CH2:30][CH3:31])[CH2:15]2)[CH:3]=1

참가 물질

3

반응물 2

HCID 7679Phenylacetyl chlorideHCID 11597936HCID 11597936, 화합물

생성물 1

HCID 11539557[4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

실험 절차

Prepared from the product from example 72 part (f) (0.70 g) and phenylacetyl chloride according to the procedure described in example 69 part (g) to give the title compound as a white solid (214 mg).

출처 및 근거

ORD 기록
ord-0362b148b29e4e6a8d6012284df9cda1
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524715B2

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